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新增賽培產(chǎn)品文章:人血清 IL-4、IL-8、IL-12、IFN-γ、TNF-α、hs-CRP 水平 測定
發(fā)布時(shí)間:2022-09-16 17:05:36

血清 α-1 抗胰蛋白酶與青年急性缺血性腦卒中患者 病情嚴(yán)重程度和短期預(yù)后的相關(guān)性
郭留芹 河南省安陽市人民醫(yī)院神經(jīng)內(nèi)科 455000 摘要目的 探討血清 α-1 抗胰蛋白酶與青年急性缺血性腦卒中患者病情嚴(yán)重程度和短期預(yù)后的相關(guān)性。 方法 選取安陽市人民醫(yī)院2008 4 月至2021 1 月神經(jīng)內(nèi)科收治的60 名首次青年急性缺血性腦卒中( AIS) 患者為病 例組,選擇同期本院健康體檢者76 例為正常對照組病例組患者在入院時(shí)按照美國國立衛(wèi)生研究院卒中量表( NIHSS) 評分分為輕度組20 ,中度組30 ,重度組10 。按照發(fā)病至手術(shù)時(shí)間的不同分為 <24 h 32 ,24 h 72 h 18 >72 h 10 。所有參與者均在入院時(shí)測定血清 α-1 抗胰蛋白酶水平比較不同組研究對象血清 α-1 抗胰蛋白 酶水平,采用多因素 Logistic 回歸分析探討預(yù)后的影響因素。結(jié)果 病例組血清 α-1 抗胰蛋白酶水平高于正常對照組 ( P <0. 05) 。隨著疾病嚴(yán)重程度增加,血清 α-1 抗胰蛋白酶水平逐漸升高( P <0. 05) 隨著發(fā)病至手術(shù)時(shí)間段延長,青年 AIS 患者血清 α-1 抗胰蛋白酶水平逐漸升高( P < 0. 05) 。預(yù)后不良組血清 α-1 抗胰蛋白酶、IL-4、IL-8、IL-12、TNF-α、 hs-CRP水平高于預(yù)后良好組,IFN-γ 水平低于預(yù)后良好組( P < 0. 05) Logistic回歸分析顯示,高水平 α-1 抗胰蛋白酶、病越嚴(yán)重、發(fā)病至治療時(shí)間越長是青年 AIS 患者預(yù)后不良的危險(xiǎn)因素( P <0. 05) 。結(jié)論 青年 AIS 患者血清 α-1 抗胰蛋 白酶水平升高且與患者病情嚴(yán)重程度和短期預(yù)后相關(guān),高水平 α-1 抗胰蛋白酶為青年 AIS 患者預(yù)后不良的危險(xiǎn)因素關(guān)鍵詞血清 α-1 抗胰蛋白酶; 青年; 急性缺血性腦卒中; 短期預(yù)后 DOI: 10. 19528 /j. issn. 1003 - 3548. 2022. 05. 003
Association of serum α-1 antitrypsin with disease severity and short-term prognosis in young patients with acute ischemic stroke
Guo Liuqin Department of Neurology,Anyang Peoples HospitalAnyang 455000,China AbstractObjective To investigate the relationship between serum α-1 antitrypsin and the severity and short-term prognosis of young patients with acute ischemic stroke. Methods Sixty first-time young patients with acute ischemic stroke ( AIS) treated in the Department of Neurology of Anyang People 's Hospital from April 2008 to January 2021 were selected as the case groupand 76 cases of physical examination in Anyang People's Hospital in the same period were selected as the normal control group. The patients in the case group were divided into mild group ( 20 cases) ,moderate group ( 30 cases) and severe group ( 10 cases) according to the National Institutes of Health Stroke Scale ( NIHSS) . According to the time from onset to operation,the patients were divided into < 24 h group ( n = 32) ,24 h and 72 h group ( n =18) and >72 h group ( n =10) . Serum alpha-1 antitrypsin levels were measured at admission for all participants. The serum α-1 antitrypsin levels of subjects in different groups were compared,and multivariate Logistic regression analysis was used to explore the prognostic factors. Results The serum α-1 antitrypsin level in case group was higher than that in control group ( P < 0. 05) . With the increase of disease severityserum α-1 antitrypsin level increased gradually ( P < 0. 05) . With the extension of time from onset to operation,serum α-1 antitrypsin level in young AIS patients gradually increased ( P <0. 05) The serum levels of α-1 antitrypsinIL-4,IL-8,IL-12,TNF-α and hs-CRP in the poor prognosis group were higher than those in the normal control group,and the levels of IFN-γ were lower than those in the good prognosis group ( P < 0. 05) . Logistic regression analysis showed that high level of α-1 antitrypsin, more serious disease and longer time from onset to treatment were risk factors for poor prognosis in young AIS patients ( P <0. 05) Conclusions Serum α-1 antitrypsin level is increased in young AIS patients·8· 臨床醫(yī)學(xué) 2022 5 月第 42 卷第 5 Clinical Medicine,May 2022,Vol. 42,No. 5which is associated with the severity of the disease and short-term prognosis. High α-1 antitrypsin level is a risk factor for poor prognosis in young AIS patients. KeywordsSerum α-1 antitrypsin; Youth; Acute ischemic stroke; Short term prognosis

血清α-1抗胰蛋白酶與青年...嚴(yán)重程度和短期預(yù)后的相關(guān)性_郭留芹.pdf


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